The Acela Amtrak route is the perfect Northeast adventure from Boston, MA, to DC. If you choose to ride the entire way, it will take around 7 hours. There are four downtown stops in New Haven, New York, Philadelphia, and Baltimore, if you're interested in exploring a new city!
The Keystone Express offers multiple daily rides from New York to Harrisonburg, PA. The trip is approximately 4 hours, with various stops in Pennsylvania, including Philadelphia. Amenities include a quiet car, Wi-Fi, and bicycle racks.
The Amtrak Hartford Line will take you from New Haven, CT, to Springfield, MA, in about an hour and a half. This scenic route will give you gorgeous views of New England's rolling hills and quickly get you to your destination.
On the Auto Train, you can go from northern Virginia to Orlando, FL, in around 19 hours. The cool thing about the Auto Train is that you can haul your car, motorcycle, bike, boat, jet-ski, or any other recreational vehicle.