You're missing the point if you come at someone with a line you've memorized, something you want to say, or a question you want to ask. Making it about you is not the way to make a connection. You must make it about them.
For example, you can take the other person's personality into account. Do they seem introverted, extroverted, or omniverted? You might be wondering how to make the conversation about them when you haven't even met them yet. You just need to be observant.