In recent years, the use of GLP-1 weight-loss medications has sparked widespread discussion, not only in medical circles but also in the celebrity world. These medications, including Ozempic, Wegovy, and Mounjaro, have helped some of Hollywood’s biggest stars achieve dramatic physical transformations. While weight loss for the rich and famous has often been the subject of scrutiny and media speculation, many have openly embraced the help of these prescription drugs, making their journeys public.
Here’s an in-depth look at some of the most shocking celebrity transformations and how weight-loss drugs played a crucial part.
Whoopi Goldberg

Whoopi Goldberg’s career in comedy and film has spanned decades, and she has been open about her struggles with weight throughout her life. In 2024, Goldberg made a significant change after seeing herself in the mirror following the filming of Till. She revealed that she weighed nearly 300 pounds at the time, but with the help of Mounjaro, Goldberg achieved a striking transformation.
Her story is a powerful example of how GLP-1 medications are being used to tackle both physical and mental health challenges, offering a new chapter for someone already at the pinnacle of their career. Goldberg’s shift in her approach to health reflects the growing trend among celebrities of taking control of their health journey through accessible, medically assisted means.
Kathy Bates
Kathy Bates has always been known for her incredible acting talent, especially in films like Misery and The Waterboy. But in 2024, Bates caught the public’s eye for a different reason: her dramatic weight loss. Having already dropped 80 pounds through lifestyle changes, Bates used Ozempic to shed an additional 20 pounds.
The actress explained to People that while the medication helped, her journey required immense effort, particularly during the pandemic when making lasting lifestyle changes became a struggle.Bates’ transformation highlights the truth behind many celebrity weight-loss stories: while medication can aid in weight loss, sustained success requires dedication, hard work, and lifestyle adjustments.
Elon Musk

Billionaire entrepreneur Elon Musk is no stranger to controversy and headline-making moves. In 2024, Musk took to social media to share his weight-loss transformation, dubbing himself “Ozempic Santa” during the Christmas season. Musk’s journey began after a viral paparazzi photo showed him looking noticeably heavier, prompting him to use the weight-loss drug Mounjaro to shed 20 pounds.
His candidness about using a GLP-1 drug demonstrates how even the most public figures are willing to embrace these medications to improve their health and physical appearance. Musk’s weight-loss story is a prime example of how celebrities use these medications not just to alter their bodies, but to maintain a level of personal health that matches their high-powered lifestyles.
Oprah Winfrey
Oprah Winfrey is no stranger to public scrutiny regarding her weight. From her early days hosting The Oprah Winfrey Show to her current role as an influential media mogul, Winfrey’s body has been a focal point of discussion. However, in 2023, Winfrey revealed that she used GLP-1 weight-loss medications as part of her health routine, alongside regular exercise and other lifestyle changes.In a candid interview with People, Oprah explained that while the medication helped, it wasn’t a magical solution.
Instead, she used it as a tool to maintain her health, ensuring her blood pressure and overall wellness were on track.Her transformation is a testament to how celebrities use these medications not just for vanity but as part of a holistic approach to better health. Oprah even stopped using the medication “cold turkey” on her 70th birthday, demonstrating her control over her journey.
Kelly Clarkson

Kelly Clarkson, the original American Idol winner, has been open about her fluctuating weight throughout her career. Known for her bubbly personality and powerhouse vocals, Clarkson’s weight gain was often attributed to her personal happiness, a fact she discussed in multiple interviews. However, in recent years, she turned to GLP-1 medications like Wegovy to manage her health amidst ongoing thyroid and autoimmune conditions.
Her transformation came at a time when she realized that her weight was affecting her physical and emotional well-being, leading her to make healthier lifestyle choices. Clarkson’s journey underscores the importance of self-awareness and the role that medications like GLP-1s can play in managing long-term health conditions, even for celebrities.
Sheryl Underwood
Sheryl Underwood, a co-host of The Talk, had long been a prominent figure in the entertainment world, but her health transformation was one of the most remarkable. In 2022, Underwood revealed that she had lost 90 pounds after deciding to take control of her health. Instead of opting for surgery, she worked with a dietician and started taking weekly Wegovy injections to help her along the way.
This decision, combined with major lifestyle changes, helped Underwood achieve a new look and a healthier life. Underwood’s story is an example of how even the most accomplished public figures can find empowerment through lifestyle changes and medically-assisted weight loss.
Jonathan Van Ness
Jonathan Van Ness, the star of Queer Eye, became an inspiration for fans when he shared his impressive 66-pound weight loss on Instagram. Van Ness openly acknowledged his use of GLP-1s, and his transformation was not just physical; he attributed much of his success to improvements in his mental health and a commitment to regular fitness.
By using weight-loss drugs like Wegovy in combination with group fitness sessions, Van Ness changed both his body and his mindset. His story resonated with many fans, demonstrating how weight loss can have broader mental and emotional benefits.
Scott Disick
Reality TV star Scott Disick’s life has been on full display for years, from his tumultuous relationship with Kourtney Kardashian to his roller-coaster ride of personal struggles. However, Disick’s latest transformation has been about reclaiming his health. After a serious car accident in 2022 and battles with substance misuse, Disick turned to Mounjaro to help him lose weight and focus on his well-being.
His story is a powerful reminder of how these medications can serve as a vital tool in overcoming personal challenges and transforming one’s life. Disick’s journey is one of self-reinvention, illustrating how celebrities are using GLP-1 medications as part of their personal health evolution.
Charles Barkley

Charles Barkley, a basketball legend, was always known for his dominant play and larger-than-life personality on the court. Off the court, however, his weight had often been the subject of conversation. In 2023, Barkley revealed that he had lost nearly 60 pounds with the help of Mounjaro after struggling with his weight for years, especially after undergoing hip replacement surgeries.
His transformation was particularly impressive given his high-profile position as a broadcaster, and his openness about using weight-loss drugs sparked conversations about how professional athletes and public figures maintain their health in the public eye. For Barkley, Mounjaro wasn’t just about appearance; it was about health and longevity, especially as he was concerned about his long-term well-being and quality of life.
Conclusion
The stories of celebrities like Oprah Winfrey, Kathy Bates, and Elon Musk demonstrate that weight-loss drugs, when used responsibly, can significantly impact health and appearance. While these drugs offer a helping hand, they are most effective when paired with a commitment to overall wellness, exercise, and lifestyle changes. From mental health to physical transformation, these A-listers are reshaping the narrative around weight loss and self-care, proving that even the most public figures have a path to personal transformation.
